Polymerization of sickle cell hemoglobin at arterial oxygen saturation impairs erythrocyte deformability.
نویسندگان
چکیده
منابع مشابه
Polymerization of sickle cell hemoglobin at arterial oxygen saturation impairs erythrocyte deformability.
We have examined the filterability of sickle erythrocytes, using an initial-flow-rate method, to determine whether sufficient hemoglobin S polymer forms at arterial oxygen saturation to adversely affect erythrocyte deformability. The amount of intracellular polymer was calculated as a function of oxygen saturation to estimate the polymerization tendency for each of eight patients with sickle ce...
متن کاملClinical Implications of the Association of Fetal Hemoglobin with Peripheral Oxygen Saturation in Sickle Cell Disease
Article history: Received 3 September 2017 Accepted 3 September 2017 Available online 5 September 2017 inhibition of HbS polymerization—and therefore remain key topics of investigation and continued interest in the field. The current report by Nkya et al. (Nkya et al., 2017) shows associations between HbF, hemoglobin, pulse rate and systolic blood pressure with peripheral oxygen saturation in a...
متن کاملIntracellular polymerization of sickle hemoglobin. Effects of cell heterogeneity.
To determine the extent to which the broad distribution in intracellular hemoglobin concentrations found in sickle erythrocytes affects the extent of intracellular polymerization of hemoglobin S, we have fractionated these cells by density using discontinuous Stractan gradients. The amount of polymer formed in the subpopulations was experimentally measured as a function of oxygen saturation usi...
متن کاملFetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania
Fetal hemoglobin (HbF) and peripheral hemoglobin oxygen saturation (SpO2) both predict clinical severity in sickle cell disease (SCD), while reticulocytosis is associated with vasculopathy, but there are few data on mechanisms. HbF, SpO2 and routine clinical and laboratory measures were available in a Tanzanian cohort of 1175 SCD individuals aged≥5years and the association with SpO2 (as respons...
متن کاملPercent of oxygen saturation of arterial hemoglobin among Bolivian Aymara at 3,900-4,000 m.
A range of variation in percent of oxygen saturation of arterial hemoglobin (SaO2) among healthy individuals at a given high altitude indicates differences in physiological hypoxemia despite uniform ambient hypoxic stress. In populations native to the Tibetan plateau, a significant portion of the variance is attributable to additive genetic factors, and there is a major gene influencing SaO2. T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1988
ISSN: 0021-9738
DOI: 10.1172/jci113504